Relevance of GNB3, MC4R and LEP genes on metabolic diseases in patients with bipolar disease and first degree relatives

  • Dr Yolanda Ocampo-Mendoza, Instituto Nacional de Psquiatria Ramon de la Fuente Muniz, Mexico
  • Dr Federico Diaz-Madrid, Hospital Psiquiatrico Fray Bernardino Alvarez, Mexico
  • Dr Mario Alanis-Garcia, Hospital Psiquiatrico Fray Bernardino Alvarez, Mexico
  • Dr Francisco Romo-Nava, Instituto Nacional de Psquiatria Ramon de la Fuente Muniz, Mexico
  • Dr Claudia Becerra-Palars, Instituto Nacional de Psquiatria Ramon de la Fuente Muniz, Mexico
  • Dr Doris Gutierrez-Mora, Instituto Nacional de Psquiatria Ramon de la Fuente Muniz, Mexico
  • Dr Carlos Berlanga-Cisneros, Instituto Nacional de Psquiatria Ramon de la Fuente Muniz, Mexico
  • Dr Adriana Diaz-Anzaldua, Instituto Nacional de Psquiatria Ramon de la Fuente Muniz, Mexico

INTRODUCTION: About 55-68% of patients with Bipolar Disorder (BD) are diagnosed with overweight and obesity. Genetic variants for LEP, LEPR, POMC, PC1, MC4R and GNB3 have been associated with obesity because they have influence on hyperphagia, hyperorexia, high blood pressure, hyperinsulinism and hyperglycemia on humans.
OBJECTIVE: To describe the prevalence of metabolic diseases in BD patients andtheir relatives and to propose a genetic component possible associated with metabolic diseases in patients with BD and their first-degree relatives.
METHODS: 104 families (104 patients with type 1 or 2 BD, and 162 first-degree relatives) were analyzed. Patients and relatives were assessed by means of SCID-I. Body measurements, weight, height, Body Mass Index (BMI), and Blood Pressure were registered.
RESULTS: 6.17% of relatives have Diabetes, 20.3% high blood pressure, and 5.5% cardiovascular diseases. 45.16% of the overweight male patients had a high metabolic risk. In females we found a 42.40% and 24.6% high risk regarding the overweight and obesity groups respectively.
CONCLUSIONS: An association between metabolic diseases and genetic variants such as those at the GNB3, MC4R and LEP loci is suggested by our findings of high risk both in patients with BD and their first-degree relatives who are not under medication for psychiatric treatment.
REFERENCES: 1. Fagiolini et al. Bipolar Disord. 2005;7(5):424-30.
2. Michalsena et al. Hunger and Mood during Extended Fasting Are Dependent on the GNB3 C825T Polymorphism. Ann Nutr Metab 2009; 54:184-188