Objective: Metabolic sydrome (MetS) prevalence is higher in bipolar disorders comparing to general population but similar with schizophrenia (1,2). A variety of studies indicated seasonal variation in blood lipid levels and such variation could result in larger numbers of people being diagnosed as having dislipidemia during diffent seasons (3). From here, we aim to evaluate seasonal variation in factors and diagnosis of MetS. Methods: 49 patients with bipolar type-I disorder, followed in a specialized mood disorders outpatient unit, were evaluated for MetS diagnosis according to new IDF definition in all seasons for one year. Seasonal variation in MetS factors were also evaluated.Results: Metabolic syndrome rates were calculated as 34,7% (n =17) in summer and autumn and, as 42,9% (n= 21) in spring and winter,. Although the MetS rates were both higher in spring and summer, it was not significant statisticaly. Among all MetS factors defined, (i.e.increased TG, decreased HDL, increased blood pressure and fasting plasma glucose) only decreased HDL revealed seasonal variation(p < 0,001).Conclusion: Our findings suggest that proportion of MetS may change seasonally. Thus, we recommend screening factors of metabolic sydromeall through seasons even no seasonal variation is witnessed in MetS. Seasonal variation in decreased HDL might be a spesific feature which has a role in aetiology of bipolar disorder type I. Further researches are needed to clarify the relation between seasonality of lipids and aetiology of bipolar disorders.Refrences:
1.CorrellCU,FredericksonAM,KaneJM,ManuP.Equallyincreasedriskformetabolicsyndromein patientswithbipolardisorderandschizophreniatreatedwithsecond-generationantipsychotics.Bipolar Disorders2008:10:788–797
2.SicrasA,RejasJ,NavarroR,SerratJ,BlancaM.Metabolicsyndromeinbipolardisorder:across-sectionalassessmentofaHealthManagementOrganizationdatabase.BipolarDisord2008:10:607–616.
3.OckeneIS,ChiribogaDE,StanekJEetal.Seasonal Variation in Serum Cholesterol Levels,Treatment Implications and Possible Mechanisms.ArchInternMed(2004)164:863-870.